Bleeding can be prolonged for several days after prostaglandin analog administration and sometimes leads to a decrease in hemoglobin levels. In clinical trials surgical evacuation was needed in 10% to 12% of women, with some studies reporting a rate as high as 20% to 30%. Heavy bleeding occurs in about 5% of the cases and may require hemostatic curettage in up to 1.4% of the cases. Postmarketing reports: Dyspepsia, gastroesophageal reflux Genitourinary Rare (less than 0.1%): Gastric bleeding, necrotising pancreatitis Very common (10% or more): Nausea (48%), vomiting (26%), dry mouth (18%), diarrhea (12%), constipation (10%), gastric discomfort, abdominal painĬommon (1% to 10%): Light or moderate cramping Very common (10% or more): Thyroid function test abnormal (18%) in patients with Cushing syndrome Gastrointestinal Adrenal insufficiency resolved in both cases with interruption of this drug and/or dexamethasone administration. The most typical symptoms of adrenal insufficiency were nausea and decreased appetite. The TSH levels returned to normal in most patients when this drug was discontinued at the end of the study.Īdrenal insufficiency was reported in two subjects (4%) in Study 400. It was reported that of the 42 Cushing syndrome patients with detectable TSH at baseline, eight (19%) had increases in TSH above the normal range, while remaining asymptomatic. Postmarketing reports: Syncope, fainting, loss of consciousness, hypotension (including orthostatic), light-headedness, tachycardia (including racing pulse, heart palpitations, heart pounding) Endocrine Rare (less than 0.1%): Myocardial infarction, induced Adam-Stokes syndrome, superficial thrombophlebitis Very common (10% or more): Hypertension (24%) The most commonly reported adverse reactions were nausea, weakness, fever/chills, vomiting, headache, diarrhea, and dizziness.
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